Radiation-Related Fatigue
bookmark this at :: del.icio.us :: Digg it
March 30, 2008


Fatigue caused by radiation therapy may be alleviated with regular exercise, according to a study of prostate cancer patients who were undergoing radiation.

Oncologists typically recommend rest in response to radiation-related fatigue, but a study of 65 patients with prostate cancer indicated that increased physical activity helped men maintain energy levels compared to just resting.


Souce: Health Sciences Institute February 2008

Labels: , ,

posted by Maggie @ 2:30 pm   0 comments
Restoring Acid-Alkaline Balance
bookmark this at :: del.icio.us :: Digg it
March 27, 2008

The most effective way to reduce acids within the body is by enacting dietary changes. A proper diet should be comprised of 60-80% alkalizing foods and 40-20% acid-forming foods.

The Standard American Diet is mostly made up of acid-forming foods including coffee, tea, wine and most proteins (with the exception of milk, butter, soft cheese and almonds) as well as most fats, cereals and sugars.

On the other hand, almost all fruits and vegetables (except for tomatoes, cranberries and blueberries) are alkalizing.

Dietary supplements can also be very effective at restoring an alkaline state to the body. Calcium, magnesium, potassium and pH balancing supplements like pH plus or Mega Greens plus MSM by perfectlyhealthy help to maintain normal pH levels. In doing so they also help regulate sugar metabolism, blood pressure, enhance energy and stabilize hormones.

Restoring proper pH balance can significantly improve and sometimes even completely reverse chronic conditions. With recognition, dietary changes and supplementation, acidosis can safely be reversed, increasing longevity and improving the quality of life.


About the author
Leigh Erin Connealy, M.D. has specialized in Integrative Medicine for over twenty years, using conventional and natural methods to determine and discover the "root of the cause" in her clinic, South Coast Medical Center for New Medicine in Irvine, California, each and every day. Many people come in to the clinic from all over the world with severe chronic illnesses that conventional medical protocols have been unsuccessful treating. She realized early on that she can truly change lives through education as well as treatment protocols. Leigh Erin Connealy, M.D. and her medical staff strives to look at the whole person while exploring the effects and relationships among nutrition, psychological and social factors, environmental effects and personal attunement. Out of frustration of trying to find the right products to help her patients she formulated the perfectlyhealthy brand of products. All perfectlyhealthy products are clinically tested. For more information on recommended products, please visit http://www.perfectlyhealthy.net/ or http://www.perfectlyhealthy.com/.

(NaturalNews)

Labels: ,

posted by Maggie @ 9:56 am   0 comments
The Problem with Chronic Acidosis
bookmark this at :: del.icio.us :: Digg it
March 23, 2008
Acidosis begins when the body cannot properly dispose of excessive acids building up in the bloodstream. The body attempts to maintain proper pH balance by eliminating the excess acids through the kidneys, lungs and skin or by neutralizing the acids during the processes of digestion and cellular metabolism. However, when too much acid is produced, the body cannot keep pace. The excess waste overwhelms the system, polluting the blood and impairing the ability of the body's cells to communicate.

In an effort to protect vital organs, the body diverts the harmful acids to store in tissues, joints and bones. This might make the organs temporarily safe, but the diversion can cause joint and skeletal problems such as osteo- and rheumatoid arthritis; skin conditions such as dermatitis and eczema; and tissue problems such as chronic fatigue and fibromyalgia.

Over time, the acids build up in the organs where they begin to disrupt normal functioning. This produces more waste, which further lowers the body's pH level. The decreased pH level means that the body is inundated with more dangerous acids and the problem becomes even more severe. Without restoring balance, cell walls harden and solidify. Our organs deteriorate as the cells die off, which further exacerbates our acidic condition. Now the body's state of acidosis is a prime breeding ground for pathogens such as bacteria, fungi, molds and parasites, which feed off of the diseased tissues and organs. Acidosis literally destroys the body from the inside out, paving the way for disease to take over.

In an attempt to neutralize excess acids, the body draws on its store of alkalizing minerals. Calcium, magnesium and sodium are drawn into the bloodstream at the expense of the bones and organs that these minerals were taken from. The bones are often the hardest hit, as they are drained of their necessary calcium reserves, leading to bone thinning and an increased risk of osteoporosis, rheumatism and fractures. The teeth also suffer as a result of the demineralization, making them more brittle and cavity-prone.

Keeping the body in an acidic state for a prolonged period of time can dramatically accelerate aging. Cellular structures become altered. Cell membranes become narrower and weaker. The cells eventually begin making "mistakes" as they try to repair and regenerate themselves. Acidosis inhibits the production of collagen and elastin. Collagen is the principal protein of our bones, cartilage, tendons and skin and provides rigidity. Elastin is a protein that gives our skin, blood vessels and organs elasticity. Without collagen and elastin, the body loses its youthful appearance, as it is no longer able to sustain moisturized and wrinkle-free skin. Internally, the body is also aging more rapidly. The premature cell death impairs brain function as the neurons can no longer properly conduct impulses. We begin to experience memory loss and the abilities to learn and reason decline.

With untreated acidosis, excess acids within the body attack the tissues and organs, resulting in inflammation, lesions and hardening of organ tissues.
The skin and kidneys are especially sensitive to the harmful acids. Hives, eczema, blotching and itching can occur from acidic sweat passing through the skin's pores.
The kidneys can become inflamed, which can lead to frequent urinary tract infections.
Hardening of tissues and inflammation are also contributors to cardiovascular disease, and the resultant increased risk of heart attack or stroke.

In a state of acidosis, there is less oxygen available to the body. Many pathogens live in oxygen-deprived environments. Acidosis, then, makes the body a prime breeding ground for harmful microorganisms to live. Acid buildup also takes a nasty toll on the body's immune function by seriously diminishing the production of white blood cells. The white blood cells that are generated are of reduced strength, making it even easier for disease and infection to take hold within the body. Dangerous microorganisms can now spread throughout the body, seeking out weakened areas. They break down tissues and interfere with biological processes, leaving behind a deadly wake of waste, which further perpetuates the acidic state.

Chronic acidosis also contributes to a state of insulin resistance within the body by interfering with glucose delivery to the cells. Normally, ordinary levels of insulin will escort glucose into the cells. With acidosis, the cell receptors fail to recognize the insulin hormone and deny it access to deposit the glucose, causing sugar to build up within the bloodstream. The pancreas, unaware of the insulin resistance, steps up insulin production in an effort to pump out enough of the hormone to remedy the situation. The body interprets the lack of glucose within the cells as starvation and begins to convert every calorie into fat. As a result, obesity and diabetes ensue.

(NaturalNews)

Labels: , , ,

posted by Maggie @ 9:32 am   0 comments
Your Health Depends on Your pH Level
bookmark this at :: del.icio.us :: Digg it
March 20, 2008
With the aging population of the United States, the incidence of so-called age-related diseases should be expected to rise. In fact the incidence of cancer, heart disease, diabetes and a host of other diseases have been steadily rising for all age groups until it has reached epidemic proportions. That is because the factors of stress, lack of physical activity, environmental pollutants and a diet high in acid-producing foods collectively create the underlying cause of most degenerative diseases: acidosis.

Proper Acid/Alkaline Balance is Fundamental
What is acidosis?
It is the reduced alkalinity of our blood and tissues. Why is this so important? Our body stays alive and healthy only because all of its 100 trillion cells communicate with each other. They do this through electrical, chemical and hormonal processes. In order for these signaling mechanisms to work, the body's internal environment must be in a slightly alkaline state.

If our body becomes too acidic, it adversely affects the functioning of all its parts: heart cells, blood cells, brain cells, nerve cells, muscle cells, bone cells, even skin and hair cells. Obviously, this leaves us vulnerable to all sorts of health problems.

The acidity or alkalinity of a substance is usually expressed as a number on the "pH" scale. The pH scale goes from 1 to 14, with 1 being most acidic, 7 being neutral and 14 most alkaline, (The symbol "pH" is the abbreviation for "power of hydrogen," a measurement of the concentration of hydrogen ions). For blood, a pH level of 7.43 - just slightly alkaline - is optimal. Levels lower than 7.0 indicate an overly acidic state (acidosis) while levels above 7.5 indicate an overly alkaline state (called alkalosis).

(NaturalNews)

Labels: ,

posted by Maggie @ 9:25 am   0 comments
Why Sunbathing (in moderation) Is Good For You
bookmark this at :: del.icio.us :: Digg it
March 18, 2008

This article was published in the New Zealand Herald on Wednesday April 18, 2007
By Jeremy Laurance

"Sunbathers needn't feel guilty any more - they're boosting their vitamin D levels.
Twenty minutes' lying in the sun could provide your best chance of avoiding colds and flu, according to new research which demonstrates that vitamin D, not vitamin C, provides the most efficient protection against cold viruses.

Vitamin D is created by the action of sunlight on the skin. The malign consequences have been revealed in a study from the United States which shows that boosting vitamin D may be the most effective way of warding off infections that cause winter colds.

The authors, from Winthrop University Hospital, Mineola, New York, who publish their findings in the journal Epidemiology and Infection, say vitamin D stimulates "innate immunity" by activating peptides in the body that attack bacteria, fungi and viruses. "Vitamin D supplementation, particularly with higher doses, may protect against the typical winter cold and flu ... Since there is an epidemic of vitamin D insufficiency in the US, the public health impact of this observation could be great," they write.

Traditional advice has been to swallow large doses of vitamin C at the first sign of a sniffle. But the latest findings suggest we may have been turning to the wrong vitamin. The revelation is the latest addition to a long list of scientific studies highlighting the beneficent qualities of a previously underrated health resource.

Vitamin D has been described as "the wonder vitamin" after a 40-year review of research found a daily dose could halve the risk of breast and colon cancer. It has also been shown to play a vital role in heart disease, cancer, diabetes, high blood pressure, schizophrenia and multiple sclerosis as well as being essential for bone health.

Widespread deficiency in the vitamin among populations in the northern hemisphere suggests it may account for several thousand premature deaths from cancers alone, American scientists from the University of San Diego said in the American Journal of Public Health in December 2005. They reviewed 63 scientific papers and concluded "public health action" to boost vitamin D levels was needed.

High rates of heart disease in Scotland have been blamed on weak sunlight and short summers. Some experts believe the benefits of the Mediterranean diet have as much to do with the sun as with the regional food. The evidence of its role in fending off two of the commonest infections in the Western world - colds and flu - has come from research by US scientists who gave supplements of the vitamin to 208 women over three years. Half the women were given a 20-microgram dose of vitamin D, increased to 50 micrograms after two years, and the other half were given a placebo. Those who took the vitamin reported a 70 per cent reduction in colds and flu, from 30 episodes to nine over the three-year study.
All the women were Afro-Caribbeans who were being tested with vitamin D supplements to see if they prevented bone loss, which is a common problem following the menopause. People with dark skins make less vitamin D when exposed to the sun and consequently tend to have lower levels.

The startling results offer a new motive to seek, in moderation, the sunlight.
Twenty minutes in the sun, with the hands, arms and face exposed, is all that is needed to get an adequate dose, but it needs to be regularly topped up through the summer. In winter the only way of maintaining levels is by taking cod liver oil or supplements.

Many countries have modified their warnings about the dangers of sunbathing in the light of the growing evidence for the benefits of vitamin D. Australia preached avoidance of the sun with its "slip, slop, slap" campaign. But the Association of Cancer Councils of Australia acknowledged two years ago that some exposure to the sun was necessary to achieve adequate vitamin D levels.

Labels: , , ,

posted by Maggie @ 9:30 am   0 comments
Sun Bathing Using Tanning Beds
bookmark this at :: del.icio.us :: Digg it
March 17, 2008

With the modern trend towards embracing anything that is easier and quicker, there has been a rise in popularity of sun bathing using tanning beds. The time spent in a tanning bed is typically much less than an afternoon at the beach, but the radiation levels are more intense than from sunlight and the UVA to UVB radiation ratio is much higher than from the sun. The wavelengths of UVA light are longer and penetrate farther into the skin. UVA radiation is a more potent cause of skin cancer than the shorter UVB light.

UVA radiation, and UVB less so, puts people at risk for DNA damage and skin cancer, but only exposure to UVB radiation will produce vitamin D, which protects against many illnesses. The amount of UVA radiation in the light of tanning beds is typically between 3 to 8 times greater than in sunlight, so you can see that tanning in the fresh air and sunlight in the natural way would appear to be much safer than using tanning beds. Go out and get your healthy glow from the sun at a safe time of day, nourish your body with good nutrition, and you will also get your quota of vitamin D.

Please don't overdo your exposure to sunlight if you want to maintain a youthful appearance. Too much sun on your skin dries it out and forms wrinkles, but not enough sun means you don't get your quota of vitamin D, so as with many things in life it's a balancing act.


Reference Woollons, A., Clingen, P.H., Price, M.L., Arlett, C.F., Green, M.H.L. (1997). Induction of mutagenic DNA damage in human fibroblasts after exposure to artificial tanning lamps. British Journal of Dermatology 1997; 137: 687-692.
posted by Maggie @ 9:07 am   0 comments
Top 12 Strategies for Staying Younger, Longer
bookmark this at :: del.icio.us :: Digg it
March 15, 2008

Time goes by day by day, and you can't stop that, but you don't have to sit back and let the effects of aging take place without a fight.

"You have the power to control how much and how fast the aging process works on your body. You can even reverse some of the damage that has already been done," says Tom Monte, author of many health and wellness books, including "Staying Young: How To Prevent, Slow or Reverse More than 60 Signs of Aging."

The aging process is caused by oxidation, the breakdown of cells and tissues as they mingle with oxygen. "It's just like the rust in a car," Mr. Monte says.

You can fight that process by adopting healthful lifestyle habits that:
* Help your immune system fight disease.
* Build up reserves of lean muscle mass.
* Prevent or slow degenerative changes.
* Rebuild damaged tissue and restore lost function.
* Help yourself
Anti-aging strategies can add to the quality of your life and health no matter how old you are, Mr. Monte says. Studies have found people in their 40s, 50s and 60s who start strength-training programs gain increased protection from injury.

Here are Mr. Monte's top 12 strategies for staying younger, longer:

Don't smoke. Each puff hastens aging's degenerative processes. Plus, smoking lowers your aerobic capacity, making it harder for you to do the things you enjoy and making you feel old before your time.

Eat foods rich in antioxidants. Vitamins A, C and E fight free-radical formation, the oxidation process that damages tissues. Eating 5½ cups of fruits and vegetables daily will help you get enough of these vitamins. Among the best sources are broccoli, cauliflower, red peppers and other red, yellow and green vegetables.

Eat lots of fiber. Dietary fiber found in beans, broccoli, bran and other complex carbohydrates helps lower cholesterol, aids digestion and defends against some kinds of cancers.

Maintain healthful cholesterol levels. Keep your total cholesterol level below 200 and your percentage of protective HDL cholesterol high. Following a diet that limits your fat intake to 30 percent or less of your total calories will help. Maintaining a healthful weight also is beneficial.

Exercise regularly. Age robs you of aerobic capacity. Performing 30 minutes of moderate activity three to four times a week can help you retain your capacity.

Build strength. As you age, you lose muscle mass; this weighs you down and reduces your ability to burn calories efficiently. Regular strength training can help reverse this trend.

Be flexible. Tight muscles limit your range of motion and increase your injury risk. A daily stretching routine that works each of your major muscle groups will help you stay supple.


Get enough sleep. While you rest, your body uses the nutrients you've consumed that day to repair the damage done by the day's activities. Not getting enough sleep keeps your immune system from doing its job and keeps your body in a state of disrepair.

Take care of your back. Keep muscles that support the spine strong and supple with cardiovascular and flexibility exercises. Use good body mechanics while lifting, standing or sitting for long periods of time.

Deal with stress. Stress is linked to many diseases and degenerative conditions associated with aging. Learn to look at problems as challenges and accept situations you can't change.

Stay close to your friends and family. A circle of support helps you deal with problems better, feel healthier and live longer.

Be nice. There's a relationship between hostility, heart disease and other stress-related problems. Look for reasons to be pleasant and to forgive people who make you angry. You may live longer as a result, and you'll probably enjoy life more.

Content provided by Staywell Custom Communications

Labels: ,

posted by Maggie @ 9:53 am   0 comments
Nissan's Electric Vehicle - A Fun Car
bookmark this at :: del.icio.us :: Digg it
March 11, 2008

Now this may be just what you're looking for. I hope they develop this into a vehicle that everyone can afford, it sounds great!!

Nissan Motor Company has developed an electric vehicle that pivots on its wheel axis, can squeeze into tight spots without backing up, and even tells its driver to relax when stressed out. The car was displayed at the Tokyo Motor show in late 2007.

The Pivo 2 is a three-seater commuter vehicle shaped like a ball. The top portion, where the seats are located, is capable of pivoting independently of the wheel frame, allowing the driver to face in any direction. Combined with the fact that the wheels also rotate 90 degrees, the Pivo 2 has an unprecedented degree of maneuverability. Parking in tight spots does not require complex maneuvering, and no reverse gear is necessary.

According to Nissan, the concept car is still too expensive for commercial sale, but the company is working on making it more accessible.

In a new feature from original Pivo concept vehicle, Nissan has added a talking robotic head to the inside of the Pivo 2's cabin, in order to keep drivers company. The robot's computer is programmed to detect a driver's mood based on their facial expressions, voice volume and speaking speed. When it detects a certain mood, the robot's head speaks preprogrammed phrases. If a driver appears stressed out, for example, the head would say "Relax, don't worry." The head is also capable of bobbing up and down.

According to the vehicle's chief designer, Masato Inoue, the goal was to make a car that people could see as more than an inanimate object and actually grow emotionally attached to.

"We want people to feel how cars can be so much fun," said Shiro Nakamura, head designer for Nissan Motors.

The Pivo 2 is fully electric and can travel up to 125 kilometers (78 miles) without being recharged. It can be charged from any normal wall socket, and does not need a special charging station or device.

Source: NaturalNews.com
posted by Maggie @ 12:15 pm   0 comments
Natural Treatment for Skin Ailments
bookmark this at :: del.icio.us :: Digg it
March 04, 2008
Combine equal parts of raw honey with pure, cold-pressed olive oil and melted beeswax, and you'll have a recipe for a natural treatment for eczema, psoriasis, and fungal infections of the skin.

In a four-week trial, topical applications of honey, olive oil and beeswax cleared up fungal infections in more than 60 percent of the study subjects. A few drops of vitamin E oil will increase the shelf-life of the mixture.


Souce: Health Sciences Institute February 2008

Labels: ,

posted by Maggie @ 2:23 pm   0 comments
Dinner Plate to Help Diabetes Weight Loss
bookmark this at :: del.icio.us :: Digg it
March 03, 2008
DIET PLATE SYSTEM
Provides measured, sectioned or calibrated areas for the various types of food, such as protein, starchy carbohydrates, vegetables, dairy and fat Once the meal is measured, it is moved to one side of the plate and then the remaining space is filled with fresh salad or vegetables



The plates measure out healthy portions.
Using a simple portion control dinner plate can help people with type 2 diabetes lose weight and decrease reliance on medication, research shows.
Canadian researchers put people with type 2 diabetes on a calorie-controlled diet for six months.
They found 17% of those who used a calibrated diet plate lost more than 5% of their body weight, compared with just 4.5% who did not.
The study appears in the journal Archives of Internal Medicine.

In the majority of cases type 2 diabetes is linked to carrying excess weight - 80% of people are overweight at diagnosis, and doctors recognise that weight loss can greatly improve the condition.
However, many people with diabetes find it hard to stick to a weight loss regime.

The researchers tested the effect of using a calibrated dinner plate and breakfast bowl that helps people to eat healthy sized portions.
On average those who used the diet plates lost 1.75% of their body weight, compared with just 0.05% in the group who had to rely on will power alone. As a result, they were also much more likely to be able to decrease their reliance on diabetes-controlling medication, including shots of insulin.

As good as drugs
Lead researcher Dr Sue Pederson said the results were comparable to those achieved by taking expensive weight loss drugs. She said: "The weight loss results are all the more impressive considering that diabetics in general do not respond well to weight loss programmes."
Dr Ian Campbell, medical director of the charity Weight Concern, said: "Losing weight is never easy and even harder for diabetics. "To achieve these results over a six month period is excellent and with no more side effects than an occasional decrease in blood glucose, easily corrected by a reduction in medication, is very impressive indeed."

Tracy Kelly, of the charity Diabetes UK, said eating a healthy balanced diet and taking regular physical activity were the best ways of controlling weight and effectively managing diabetes.
"Cutting down on portion sizes and eating balanced meals will help people control their weight, therefore some people may find this plate useful. However, controlling weight can be achieved effectively without spending extra money. A healthy balanced diet should be based on carbohydrates and be low in fat, sugar and salt with plenty of fruit and vegetables."

Labels: , , ,

posted by Maggie @ 10:58 am   0 comments
Linking Obesity and Cancer
bookmark this at :: del.icio.us :: Digg it
March 02, 2008
This continues the thoughts we started yesterday on treating cancer.

"Fueling cancer

Still, this notion might have stalled without two other developments.
* First, epidemiological studies began to find links between cancer and the insulin-IGF axis in people.
* Then, the entire field of cancer treatment underwent a transformation.

"What got people's attention was the epidemiologic data," says Doug Yee of the University of Minnesota Cancer Center in Minneapolis. In 1998, researchers reported in the journal Science that the risk of prostate cancer among men with the highest circulating levels of IGF-1 was four times as great as the risk among men with the lowest IGF-1 levels. Similar findings quickly followed in breast, colon, and other cancers.

So far, colon cancer has the most consistent association with insulin and IGF-1 levels, says Edward Giovannucci of the Harvard School of Public Health, a coauthor of the 1998 Science study. In 1999, he and his colleagues reported that colon cancer rates were more than twice as high among men who had the highest levels of IGF-1 as they were among men with the lowest IGF-1 levels.

Such findings fit with global patterns of the disease. "If you look at the rates of colon cancer across the world, populations where you expect people to have low insulin invariably have low rates of colon cancer," Giovannucci says. Physical activity and reduced calorie intake can lower insulin levels; populations with more sedentary jobs and calorie-dense diets have higher rates of obesity and higher insulin levels.

"Once you become economically developed, colon cancer rates go up," Giovannucci says. Also, the risks for colon cancer read largely like a list of red flags for type 2 diabetes. Diabetes itself is a risk factor for colon cancer.

Scientists are quick to point out that a higher insulin level isn't the only chemical change that can occur with obesity. Levels of hormones that cause inflammation also rise, as do sex hormones, which can be produced in fat tissue. These and other changes in the body could themselves drive cancer. Or all these fluctuations could work in concert to feed malignancies.

And it might be not only the IGF-1 of middle age that matters, but also the IGF-1 production that orchestrates development early in life. Studies have suggested that babies born at the highest birth weights—and children experiencing early growth spurts—have a greater risk of cancer as adults.

While epidemiologists gathered evidence for a relationship between insulin and cancer, a second, unrelated advance gave the insulin-cancer connection new life: treatment success using antibodies that can attach to precise targets. Antibody-based drugs are large molecules that take the parking space so its rightful owner can't use it. Herceptin, an antibody-based breast cancer treatment, came on the market in 1998, followed by others. Targeted antibodies were suddenly more than theory.

"I think once people got more comfortable making these drugs, the floodgates opened," says Yee. And when pharmaceutical companies started casting for other promising targets for antibody development, the IGF-1 receptor suddenly looked attractive.

"They turned around and said, 'You know, there's this IGF receptor,'" says LeRoith of Mount Sinai. Drug development didn't happen, and perhaps couldn't have, until epidemiology and the technology caught up with the laboratory evidence. "

Labels: , , ,

posted by Maggie @ 1:03 pm   0 comments
The Link Between Obesity and Cancer
bookmark this at :: del.icio.us :: Digg it
March 01, 2008
"Heavy hormones

Lower weight and more physical activity can affect the production of insulin, the hormone that allows the body to soak up fuel. After a meal, food is broken down into glucose, which is the body's main source of energy. Insulin triggers cells to take up and use glucose. As a person gains excess weight, the cells can become resistant to insulin's actions. To compensate, the pancreas begins to produce more insulin, but it can't stay in overdrive indefinitely. Eventually, insulin production will fall and blood glucose levels rise in some people.

The potent hormone IGF-1 and the related IGF-2 are very similar to insulin, helping support rapidly dividing cells, especially during childhood and adolescence. IGF-1 is a powerful driver of cell growth and body size: A toy poodle is a standard poodle with a faulty IGF-1 system.

The link between these insulinlike hormones and obesity is less clear than the connection between insulin and obesity. Although insulin and IGF-1 have individual parking places, or receptors, on a cell, some experiments suggest that at high enough levels, insulin starts to trespass on the IGF-1 receptor, LeRoith says.

In the late 1980s, laboratory researchers demonstrated that IGF-1 might have a role in cancer. Tumor cells were found to contain the IGF-1 receptor. In 1989, experiments with mice showed that blocking the receptor with an antibody could stop tumor growth. Researchers also found that mice bred to lack IGF-1 receptors in all their tissues were born tiny, thereby establishing the hormone's significance in growth. More important for cancer research, cells taken from the miniature mice lacking IGF-1 receptors could not be transformed into tumor cells.

"A cancer cell has to have the IGF-1 receptor," says Renato Baserga of the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, one of the field's pioneers. "If not, it cannot grow."

At first, results like these were puzzling. Unlike cancer genes that encode other proteins and start down the path to cancer after mutating, the IGF-1 receptor gene wasn't altered in tumors. Also, IGF-1 receptors show up in normal tissues throughout the body. The hormone itself is such a basic substance for animal life that even flies produce it. It was hard to imagine that a normal receptor found in normal cells could have anything to do with cancer.

Then scientists had an idea. Malignant cells may be overly dependent on IGF-1 receptors, on a scale far surpassing the dependence of normal cells. A tumor is like a car—a gas-guzzling Hummer—with a stuck accelerator and no brakes. Even if IGF-1 doesn't spark the ignition, the hormone keeps the gas tank full. Block IGF-1, according to this line of thinking, and the tumor suddenly finds itself running on empty. "

More on this interesting and thought provoking topic tomorrow.

Labels: , , ,

posted by Maggie @ 12:56 pm   0 comments
Business Seminars Australia
Previous Posts
Add this blog to my Technorati Favorites!

Archives
Links

Affiliates

BLOGGER disclosure policy
Digg
technorati
del.icio.us